The Minimum Quadric Differences (MQD) algorithm is to simply calculate
the pixel value differences between the search windows.
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The accuracy of the cross-correlation algorithm and the MQD algorithm are almost the same. However, the MQD algorithm may be more robust than the correlation algorithm in certain situations. For example, the correlation algorithm does not work well for images containing no particles such as speckle images. However, there is a price to pay - the MQD algorithm is in general slower than the correlation algorithm.